An L-ascorbic acid derivative with antioxidant and radioprotective activities; scavenges DPPH radicals in a cell-free assay (EC50 = 61 μM in 60% ethanol); inhibits γ-radiation-induced cell death in CHO-10B2 and radiosensitive xrs5 cells

2-O-α-D-Glucopyranosyl-L-ascorbic Acid – 25 g

Brand:
Cayman
CAS:
129499-78-1
Storage:
-20
UN-No:
Non-Hazardous - /

2-O-α-D-Glucopyranosyl-L-ascorbic acid (AA-2G) is a glucosylated derivative of L-ascorbic acid (Item No. 14656) that has antioxidant and radioprotective activities.{54442,54443,54444} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (EC50 = 61 μM in 60% ethanol).{54442} AA-2G (5 mM) inhibits γ-radiation-induced cell death in CHO-10B2 and radiosensitive xrs5 cells, as well as UVC- or broadband UVB-induced cell death in CHO-10B2 and UV-sensitive UV135 cells.{54443} It is hydrolyzed to ascorbic acid by α-glucosidase and increases serum levels of ascorbic acid in rats and guinea pigs when administered orally at doses of 19.2 and 96 mg/animal, respectively.{54444} AA-2G (19.2 mg/animal per day) reverses weight loss and inhibits subcutaneous hemorrhage in guinea pigs fed a vitamin C-deficient diet.  

 

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SKU: 31402 - 25 g Category:

Description

An L-ascorbic acid derivative with antioxidant and radioprotective activities; scavenges DPPH radicals in a cell-free assay (EC50 = 61 μM in 60% ethanol); inhibits γ-radiation-induced cell death in CHO-10B2 and radiosensitive xrs5 cells, as well as UVC- or broadband UVB-induced cell death in CHO-10B2 and UV-sensitive UV135 cells, at 5 mM; increases serum levels of ascorbic acid in rats and guinea pigs at 19.2 and 96 mg/animal, p.o., respectively; reverses weight loss and inhibits subcutaneous hemorrhage in guinea pigs fed a vitamin C-deficient diet at 19.2 mg/animal per day

Formal name:

Synonyms:  AA-2G|Asc2G|Ascorbic Acid 2-glucoside

Molecular weight: 338.3

CAS: 129499-78-1

Purity: ≥95%

Formulation: A crystalline solid

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