An agonist of P2Y receptors (EC50s = 5.13

2-Methylthioadenosine diphosphate (sodium salt) – 1 mg

Brand:
Cayman
CAS:
475193-31-8
Storage:
-20
UN-No:
Non-Hazardous - /

2-Methylthioadenosine diphosphate (2-MeSADP) is an agonist of purinergic P2Y receptors with EC50s of 5.13 and 0.89 nM for human recombinant P2Y1 and P2Y12 receptors, respectively.{43571} It also acts as an agonist at rat P2Y1 and P2Y12 and mouse P2Y13 receptors (EC50s = 0.58, 0.89, and 6.2 nM, respectively).{43571,43572} It induces platelet aggregation and inhibits cyclic AMP accumulation in platelet-rich plasma stimulated by prostaglandin E1 (PGE1; Item No. 13010) more potently than ADP (Item Nos. 21121 | 16778).{43573}  

 

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Description

An agonist of P2Y receptors (EC50s = 5.13, 0.89, 0.58, 0.89, and 6.2 for human P2Y1 and P2Y12, rat P2Y1 and P2Y12, and mouse P2Y13 receptors, respectively); induces platelet aggregation and inhibits cyclic AMP accumulation in PGE1-stimulated platelet-rich plasma more potently than ADP

Formal name: 2-(methylthio)-adenosine 5′-(trihydrogen diphosphate), trisodium salt

Synonyms:  2-MeSADP|2-Methylthio-ADP

Molecular weight: 539.2

CAS: 475193-31-8

Purity:

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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