A natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol; has anticancer agent activity as an angiogenesis inhibitor via the HIF-1α pathway; levels are significantly lower in women with severe pre-eclampsia

2-Methoxyestradiol – 5 mg

Brand:
Cayman
CAS:
362-07-2
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

2-methoxy Estradiol (2-ME2) is a natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. Administration of 2-hydroxy estradiol (2-HE2) to rats results in formation and clearance of 2-ME2 with t½ values of 7.9 and 24.9 minutes, respectively.{16610} 2-ME2 exhibits no affinity for estrogen receptors. 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1α pathway.{16608,16609,16611} The levels of COMT and 2-ME2 are significantly lower in women with severe pre-eclampsia.{16513}  

 

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SKU: 13021 - 5 mg Category:

Description

A natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol; has anticancer agent activity as an angiogenesis inhibitor via the HIF-1α pathway; levels are significantly lower in women with severe pre-eclampsia

Formal name: 2-methoxy-estra-1,3,5(10)-triene-3,17β-diol

Synonyms:  2-Hydroxyestradiol 2-methyl ether|2-ME2|NSC 659853|Panzem

Molecular weight: 302.4

CAS: 362-07-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Angiogenesis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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