An adenosine A1 receptor agonist; selective for adenosine A1 over A2A and A3 receptors in radioligand binding assays (Kis = 1.8

2′-MeCCPA – 10 mg

Brand:
Cayman
CAS:
205171-12-6
Storage:
-20
UN-No:
Non-Hazardous - /

2′-MeCCPA is an adenosine A1 receptor agonist.{61045} It is selective for adenosine A1 over A2A and A3 receptors in radioligand binding assays (Kis = 1.8, 3,900 and 5,000 nM, respectively) and inhibits forskolin-induced activation of adenylyl cyclase in rat cortical membranes (IC50 = 13.1 nM). 2′-MeCCPA (2.5-5 mg/kg) increases tail flick latency in the hot plate test and inhibits formalin-induced late nocifensive behavior in rats.{61046}  

 

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SKU: 30935 - 10 mg Category:

Description

An adenosine A1 receptor agonist; selective for adenosine A1 over A2A and A3 receptors in radioligand binding assays (Kis = 1.8, 3,900 and 5,000 nM, respectively); inhibits forskolin-induced activation of adenylyl cyclase in rat cortical membranes (IC50 = 13.1 nM); increases tail flick latency in the hot plate test and inhibits formalin-induced late nocifensive behavior in rats from 2.5-5 mg/kg

Formal name: 2-chloro-N-cyclopentyl-2′-C-methyl-adenosine

Synonyms: 

Molecular weight: 383.8

CAS: 205171-12-6

Purity: ≥98%

Formulation: A crystalline solid

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