A potent MT1 receptor agonist (Ki = 28 pM); 5-fold selective for MT1 over MT2; inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 (EC50 = 11 pM); has been used to characterize the role of MT1 in melatonin-mediated signaling

2-Iodomelatonin – 10 mg

Brand:
Cayman
CAS:
93515-00-5
Storage:
-20
UN-No:
Non-Hazardous - /

2-iodomelatonin is a potent agonist of melatonin receptor 1 (MT1; Ki = 28 pM) that is 5-fold selective for MT1 over MT2.{26017,26021} It inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 30-fold more potently than melatonin (Item No. 14427) with an EC50 value of 11 pM. 2-iodomelatonin has been used to characterize the role of MT1 in melatonin-mediated signaling.{40764,40765}  

 

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Description

A potent MT1 receptor agonist (Ki = 28 pM); 5-fold selective for MT1 over MT2; inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 (EC50 = 11 pM); has been used to characterize the role of MT1 in melatonin-mediated signaling,

Formal name: N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]-acetamide

Synonyms: 

Molecular weight: 358.2

CAS: 93515-00-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience

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