A cyclic guanidino analog of biotin that acts as a reversible inhibitor of iNOS and nNOS (Kis = 21.8 and 37.5 µM for mouse iNOS and rat nNOS

2-Iminobiotin – 100 mg

Brand:
Cayman
CAS:
13395-35-2
Storage:
-20
UN-No:
Non-Hazardous - /

2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Kis = 21.8 and 37.5 µM for mouse iNOS and rat nNOS, respectively).{32524} It also provides sex-specific neuroprotection against hypoxia-ischemia in neonatal rats by an NO-independent mechanism.{32522} 2-Iminobiotin has also been used to capture membrane-bound proteins through biotin-avidin interactions.{32523}  

 

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Description

A cyclic guanidino analog of biotin that acts as a reversible inhibitor of iNOS and nNOS (Kis = 21.8 and 37.5 µM for mouse iNOS and rat nNOS, respectively)

Formal name: (3aR,6S,6aS)-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-6-pentanoic acid

Synonyms:  Guanidinobiotin

Molecular weight: 243.3

CAS: 13395-35-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Nitric Oxide Synthases||Research Area|Neuroscience|Neuroprotection

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