2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.{26620,26621,23432} The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the HP-β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.{26620,21228}
A cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group
Formal name: 2-hydroxypropyl ethers β-cyclodextrin
Synonyms: HP-β-CD
Molecular weight: 1,541.60
CAS: 128446-35-5
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Carbohydrates||Research Area|Toxicology
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