A CYP450 metabolite of estradiol with low affinity for estrogen receptors; rapidly metabolized to 2-ME2 with a half-life of approximately ten minutes in rat

2-Hydroxyestradiol – 10 mg

Brand:
Cayman
CAS:
362-05-0
Storage:
-20
UN-No:
Non-Hazardous - /

2-hydroxy Estradiol (2-HE2) is a cytochrome P450 metabolite of estradiol with low affinity for estrogen receptors. 2-HE is rapidly metabolized by catechol-O-methyltransferase (COMT) to form 2-methoxy estradiol (2-ME2) with a half-life of approximately ten minutes in rat.{16610} 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1a pathway.{16608,16609,16611} Due to the rapid metabolism of 2-HE2, the effects attributed to 2-HE2, may actually be those of 2-ME2.{16610}  

 

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SKU: 13019 - 10 mg Category:

Description

A CYP450 metabolite of estradiol with low affinity for estrogen receptors; rapidly metabolized to 2-ME2 with a half-life of approximately ten minutes in rat

Formal name: estra-1,3,5(10)-triene-2,3,17β-triol

Synonyms:  2-HE2|NSC 61711

Molecular weight: 288.4

CAS: 362-05-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Angiogenesis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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