An active metabolite of atorvastatin; formed from atorvastatin by CYP3A4; inhibits lipid hydroperoxide formation and copper sulfate-induced TBARS formation in DLPC vesicles and human LDL

2-hydroxy Atorvastatin (calcium salt) – 1 mg

Brand:
Cayman
CAS:
265989-46-6
Storage:
-20
UN-No:
Non-Hazardous - /

2-hydroxy Atorvastatin is an active metabolite of the HMG-CoA reductase inhibitor atorvastatin (Item No. 10493).{57004} 2-hydroxy Atorvastatin is formed from atorvastatin by the cytochrome P450 (CYP) isoform CYP3A4. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC; Item No. 20954) vesicles and human LDL, respectively, in a concentration-dependent manner.{57005} 2-hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD.{57006}  

 

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SKU: 30974 - 1 mg Category:

Description

An active metabolite of atorvastatin; formed from atorvastatin by CYP3A4; inhibits lipid hydroperoxide formation and copper sulfate-induced TBARS formation in DLPC vesicles and human LDL, respectively, in a concentration-dependent manner; reduces OGD-induced cell death in primary rat cortical neurons and increases phosphorylation of CREB in GABAergic neurons at 600 nM following OGD

Formal name: (βR,δR)-2-(4-fluorophenyl)-β,δ-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic acid, calcium salt (2:1)

Synonyms:  o-hydroxy Atorvastatin|ortho-hydroxy Atorvastatin|BMS 243887-01|PD 152873

Molecular weight: 593.7

CAS: 265989-46-6

Purity: ≥95%

Formulation: A solid

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