A phenol with diverse biological activities; active against Gram-positive (MICs = 100-200 µg/ml) and Gram-negative bacteria (MICs = 125-200 µg/ml)

2-Hydroxy-4-methoxybenzaldehyde – 25 mg

Brand:
Cayman
CAS:
673-22-3
Storage:
-20
UN-No:
Non-Hazardous - /

2-Hydroxy-4-methoxybenzaldehyde is a phenol found in the root bark essential oil of P. sepium that has diverse biological activities, including antibacterial, antifungal, fungicidal, antioxidant, anti-virulence, and metal chelating properties.{55018,55019,55020} It is active against Gram-positive (MICs = 100-200 µg/ml) and Gram-negative bacteria (MICs = 125-200 µg/ml), as well as the fungus C. albicans and the phytopathogenic fungus M. oryzae (MICs = 150 and 300 µg/ml, respectively). 2-Hydroxy-4-methoxybenzaldehyde scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in a cell-free assay (IC50 = 9.04 mg/ml) and acts as a metal chelator, inhibiting ferrozine-Fe2+ complex formation with an IC50 value of 2.31 mg/ml. It reduces the production of the virulence factor staphyloxanthin in clinical isolates of methicillin-resistant S. aureus (MRSA) when used at a concentration of 200 µg/ml and decreases the expression of the MRSA virulence regulatory genes saeS, geh, crtM, and sigB.{55019} 2-Hydroxy-4-methoxybenzaldehyde, when used in combination with the antibiotics amikacin (Item No. 15405), gentamicin, cefotaxime (Item No. 16040), vancomycin (Item No. 15327), or tetracycline (Item No. 14328), increases MRSA antibiotic sensitivity. It is also an intermediate in the synthesis of Schiff base-metal complexes with antiproliferative activity.{55020}  

 

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SKU: 30091 - 25 mg Category:

Description

A phenol with diverse biological activities; active against Gram-positive (MICs = 100-200 µg/ml) and Gram-negative bacteria (MICs = 125-200 µg/ml), as well as the fungus C. albicans and the phytopathogenic fungus M. oryzae (MICs = 150 and 300 µg/ml, respectively); scavenges DPPH radicals in a cell-free assay (IC50 = 9.04 mg/ml) and acts as a metal chelator (IC50 = 2.31 mg/ml); reduces the production of the virulence factor staphyloxanthin in clinical isolates of MRSA at 200 µg/ml; increases MRSA antibiotic sensitivity when used in combination with various antibiotics; an intermediate in the synthesis of Schiff base-metal complexes with antiproliferative activity

Formal name:

Synonyms:  4-Methoxysalicylaldehyde|NSC 155334

Molecular weight: 152.1

CAS: 673-22-3

Purity: ≥95%

Formulation: A crystalline solid

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