A quorum-sensing signal molecule produced by P. aeruginosa in response to increasing cell density; increases expression of the lasB gene

2-heptyl-3-hydroxy-4(1H)-Quinolone – 5 mg

Brand:
Cayman
CAS:
108985-27-9
Storage:
-20
UN-No:
Non-Hazardous - /

2-heptyl-3-hydroxy-4(1H)-Quinolone is a quorum-sensing signaling molecule produced by P. aeruginosa in response to increasing cell density.{45615} It increases expression of the lasB gene, which encodes the virulence factor elastase, in P. aeruginosa (EC50 = ~30 µM in a reporter cell assay). 2-heptyl-3-hydroxy-4(1H)-Quinolone (60 µM) increases secretion of the metabolite pyocyanin (Item No. 10009594) and the lectin PA-IL, as well as increases biofilm production in P. aeruginosa populations.{45616} It also reduces iron levels in P. aeruginosa growth media when used at a concentration of 40 µM and acts as an iron chelator in a Fe(III)-sulfate solution.{45617}  

 

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SKU: 29186 - 5 mg Category:

Description

A quorum-sensing signal molecule produced by P. aeruginosa in response to increasing cell density; increases expression of the lasB gene, which encodes the virulence factor elastase, in P. aeruginosa (EC50 = ~30 µM in a reporter cell assay); increases secretion of pyocyanin and PA-IL, as well as increases biofilm production in P. aeruginosa populations at 60 µM; an iron chelator in P. aeruginosa growth media at 40 µM

Formal name: 2-heptyl-3-hydroxy-4(1H)-quinolinone

Synonyms:  Pseudomonas Quinolone Signal|PQS

Molecular weight: 259.3

CAS: 108985-27-9

Purity: ≥95%

Formulation: A solid

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