A synthetic analog of curcumin that activates enzymes which catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway; increases NQO1 activity

2-HBA – 5 mg

Brand:
Cayman
CAS:
131359-24-5
Storage:
-20
UN-No:
Non-Hazardous - /

Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} 2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. As a double Michael reaction acceptor, 2-HBA can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination, which leads to enhanced expression of antioxidative and cytoprotective enzymes.{21471} 2-HBA doubles the specific activity of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) in Hepa1c1c7 cells at 0.15 μM.{21472} In rapidly dividing mouse leukemia L1210 cells, 0.6 μM 2-HBA increases the activities of NQO1, glutathione reductase, and the levels of total glutathione.{21472,21473} At 5-15 μM, 2-HBA causes G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.{21472}  

 

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SKU: 11879 - 5 mg Category:

Description

A synthetic analog of curcumin that activates enzymes which catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway; increases NQO1 activity, glutathione reductase activity, and total glutathione levels in vitro at 0.6 – 0.15 μM; causes G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis at 5-15 μM

Formal name: (1E,4E)-1,5-bis(2-hydroxyphenyl)-1,4-pentadien-3-one

Synonyms:  Bis(2-hydroxybenzylidene)acetone

Molecular weight: 266.3

CAS: 131359-24-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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