Used as a substrate of guanylate kinases to generate dGDP

2′-Deoxyguanosine 5′-monophosphate (sodium salt hydrate) – 5 g

Brand:
Cayman
CAS:
146877-98-7
Storage:
-20
UN-No:
Non-Hazardous - /

2′-Deoxyguanosine 5′-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum.{26880,26883} In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.{26882,26881}  

 

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Description

Used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis; can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum

Formal name: 2′-deoxy-5′-guanylic acid, disodium salt hydrate

Synonyms:  dGMP

Molecular weight: 391.2

CAS: 146877-98-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Research Area|Cell Biology||Research Area|Endocrinology & Metabolism|Nutrient Sensing||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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