A non-metabolizable glucose analog widely used as a glycolytic inhibitor to study metabolic activity with related to cancer

2-deoxy-D-Glucose – 25 g

Brand:
Cayman
CAS:
154-17-6
Storage:
-20
UN-No:
Non-Hazardous - /

2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis.{22664,22663} This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response.{22664} 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models.{22665,22663,22666}  

 

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Description

A non-metabolizable glucose analog widely used as a glycolytic inhibitor to study metabolic activity with related to cancer, neurodegeneration, calorie restriction, and aging

Formal name: 2-deoxy-D-arabino-hexose

Synonyms:  Ba 2758|NSC 15193

Molecular weight: 164.2

CAS: 154-17-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Death||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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