A synthetic flavone inhibitor of sumoylation; inhibits sumoylation completely in microfluidic electrophoretic mobility shift and kinetic assays at a concentration of 30 µM; inhibits sumoylation in breast cancer cell lines; disrupts the transfer of SUMO to the substrate; neuroprotective against Aβ aggregation and toxicity; has antioxidant properties

2-D08 – 10 mg

Brand:
Cayman
CAS:
144707-18-6
Storage:
-20
UN-No:
Non-Hazardous - /

2-D08 is a synthetic flavone that inhibits sumoylation.{38137} It completely inhibits sumoylation in microfluidic electrophoretic mobility shift and kinetic assays at a concentration of 30 µM. 2-D08 inhibits sumoylation of topoisomerase I in the breast cancer cell lines ZR-75-1 and BT-474.{38136} It specifically disrupts the transfer of SUMO from the E2 enzyme (UBC9) thioester conjugate to the substrate. 2-D08 prevents amyloid-β (Aβ) (1-42) aggregation and Aβ-induced toxicity in PC12 cells.{38138} It also has antioxidant properties.{38135}  

 

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Description

A synthetic flavone inhibitor of sumoylation; inhibits sumoylation completely in microfluidic electrophoretic mobility shift and kinetic assays at a concentration of 30 µM; inhibits sumoylation in breast cancer cell lines; disrupts the transfer of SUMO to the substrate; neuroprotective against Aβ aggregation and toxicity; has antioxidant properties

Formal name: 2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 270.2

CAS: 144707-18-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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