Description
An adenosine A3 receptor agonist; binds selectively to adenosine A3 receptors (Ki = 0.33 nM) over A1 and A2A receptors (Kis = 820 and 470 nM, respectively) and inhibits adenylate cyclase activity (IC50 = 66.8 nM); inhibits proliferation of B16/F10 melanoma cells and increases proliferation of murine bone marrow cells in vitro at 10 and 100 nM; induces accumulation of cells in the G0/G1 phase of the cell cycle and induces apoptosis at 100 nM; prevents the development of lung metastatic foci in a B16/F10 mouse model of lung metastasis and reverses decreases in the number of white blood cells and neutrophils induced by cyclophosphamide at 6 µg/kg
Formal name: 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide
Synonyms: 2-Chloro-IB-MECA|CF 102|Namodenoson
Molecular weight: 544.7
CAS: 163042-96-4
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis
