An adenosine A3 receptor agonist; binds selectively to adenosine A3 receptors (Ki = 0.33 nM) over A1 and A2A receptors (Kis = 820 and 470 nM

2-Cl-IB-MECA – 25 mg

Brand:
Cayman
CAS:
163042-96-4
Storage:
-20
UN-No:
Non-Hazardous - /

2-Cl-IB-MECA is an adenosine A3 receptor agonist.{27924} It binds selectively to adenosine A3 receptors (Ki = 0.33 nM) over A1 and A2A receptors (Kis = 820 and 470 nM, respectively) and inhibits adenylate cyclase activity with an IC50 value of 66.8 nM in CHO cell membranes expressing rat A3 receptors. 2-Cl-IB-MECA (10 and 100 nM) inhibits proliferation of B16/F10 melanoma cells and increases proliferation of murine bone marrow cells in vitro, effects that can be blocked by the A3 receptor antagonist MRS1523 (Item No. 17128).{47509} It induces accumulation of cells in the G0/G1 phase of the cell cycle and induces apoptosis when used at a concentration of 100 nM. 2-Cl-IB-MECA (6 µg/mg) prevents the development of lung metastatic foci in a B16/F10 mouse model of lung metastasis and reverses decreases in the number of white blood cells and neutrophils induced by cyclophosphamide (Item No. 13849).  

 

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Description

An adenosine A3 receptor agonist; binds selectively to adenosine A3 receptors (Ki = 0.33 nM) over A1 and A2A receptors (Kis = 820 and 470 nM, respectively) and inhibits adenylate cyclase activity (IC50 = 66.8 nM); inhibits proliferation of B16/F10 melanoma cells and increases proliferation of murine bone marrow cells in vitro at 10 and 100 nM; induces accumulation of cells in the G0/G1 phase of the cell cycle and induces apoptosis at 100 nM; prevents the development of lung metastatic foci in a B16/F10 mouse model of lung metastasis and reverses decreases in the number of white blood cells and neutrophils induced by cyclophosphamide at 6 µg/kg

Formal name: 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide

Synonyms:  2-Chloro-IB-MECA|CF 102|Namodenoson

Molecular weight: 544.7

CAS: 163042-96-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis

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