A metabolically stable adenosine analog that binds to adenosine A1

2-Chloroadenosine – 50 mg

Brand:
Cayman
CAS:
146-77-0
Storage:
-20
UN-No:
Non-Hazardous - /

2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively.{19450} CADO has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures.{19452} It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats.{19453,19450}  

 

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Description

A metabolically stable adenosine analog that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively; anticonvulsive activity in a rat model of generalized seizures

Formal name: 2-chloro-adenosine

Synonyms:  Antibiotic AT-265B|CADO|NSC 36896

Molecular weight: 301.7

CAS: 146-77-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma

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