A monochlorinated form of palmitic acid; produced in an MPO- and time-dependent manner in neutrophils stimulated by PMA; induces NETosis in human neutrophils

2-chloro Palmitic Acid – 5 mg

Brand:
Cayman
CAS:
19117-92-1
Storage:
-20
UN-No:
Non-Hazardous - /

2-chloro Palmitic acid is a monochlorinated form of palmitic acid (Item No. 10006627). It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014). 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli.{43363} It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM.{43481,43482} 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.{43483}  

 

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Description

A monochlorinated form of palmitic acid; produced in an MPO- and time-dependent manner in neutrophils stimulated by PMA; induces NETosis in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with ecDNA, and trapping of E. coli at 10 μM; increases COX-2 protein levels in HCAECs at 50 μM; increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, at 10 μM; induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells at 10-50 μM

Formal name: 2-chloro-hexadecanoic acid

Synonyms:  2-ClHA|2-CLPA

Molecular weight: 290.9

CAS: 19117-92-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity|NETosis||Research Area|Lipid Biochemistry

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