A ribonucleoside with broad-spectrum antiviral activity; reduces the number of viral plaques in BHK-21 cells infected with dengue type 2

2′-C-Methylcytidine – 5 mg

Brand:
Cayman
CAS:
20724-73-6
Storage:
-20
UN-No:
Non-Hazardous - /

2′-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity.{37119} It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human coronavirus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM).{37120} In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.{37121}  

 

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SKU: 22887 - 5 mg Category:

Description

A ribonucleoside with broad-spectrum antiviral activity; reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses (EC50s = 95, 26, 80, and 75 μM, respectively); inhibits HCV replication (EC50 = 2.2 μM in a replicon assay); protects MDBK cells from BVDV and HCoV infection (EC50s = 2.2 and 90 μM, respectively); reduces infectious virus yield in BHK-21 cells infected with FMDV and SVDV (EC50s = 6.4 and 45.2 μM, respectively); reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection

Formal name: 2′-C-methyl-cytidine

Synonyms:  2CMC

Molecular weight: 257.2

CAS: 20724-73-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Coronaviruses||Research Area|Infectious Disease|Viral Diseases|Dengue||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|West Nile Virus||Research Area|Infectious Disease|Viral Diseases|Yellow Fever

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