A potent and selective agonist of CB1 and GPR55 (EC50s = 10

2-Arachidonyl Glycerol ether – 25 mg

Brand:
Cayman
CAS:
222723-55-9
Storage:
-80
UN-No:
Excepted Quantity - 1170 / 3

2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay).{8945} It is a potent and selective agonist of CB1 and GPR55 with EC50 values of 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively.{17583} 2-AG ether displays the typical tetrad of CB activities in mice.{8945} It is more chemically stable than 2-AG (Item No. 62160), with an endogenous half-life of hours rather than minutes.{10462} However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses.{7182} 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 µg per eye.{10462} It increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork.{14129} Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.{38343}  

 

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SKU: 62165 - 25 mg Category:

Description

A potent and selective agonist of CB1 and GPR55 (EC50s = 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively); binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay); displays the typical tetrad of CB activities in mice; more chemically stable than 2-AG with an endogenous half-life of hours rather than minutes; 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses; reduces intraocular pressure in rabbits when administered at doses exceeding 50 µg per eye; increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets,

Formal name: 5Z,8Z,11Z,14Z-eicosatetraen-2-glyceryl ether

Synonyms:  2-AG ether|Noladin

Molecular weight: 364.6

CAS: 222723-55-9

Purity: ≥98%

Formulation: A solution in ethanol

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