An endogenous CB1 and CB2 receptor agonist (Kis = 25.3-472 and 145-1

2-Arachidonoyl Glycerol – 10 mg

Brand:
Cayman
CAS:
53847-30-6
Storage:
-80
UN-No:
De Minimis - 1648 / 3

2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively).{7183,7182,7912} Unlike arachidonoyl ethanolamide (AEA; Item No. 90050), 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol (MAG) found in rat brain.{7183,6819} Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol (DAG) lipase.{7183} 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism.{7182} 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase (FAAH), with MAG lipase likely being the principle metabolizing enzyme in vivo.{11364}  

 

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SKU: 62160 - 10 mg Category:

Description

An endogenous CB1 and CB2 receptor agonist (Kis = 25.3-472 and 145-1,400 nM, respectively); the most abundant molecular species of MAG found in rat brain; formation is calcium-dependent and is mediated by the activities of PLC and DAG lipase; induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism at a concentration of 0.3 nM; metabolized in vitro by MAG lipase and FAAH, with MAG lipase likely being the principle metabolizing enzyme in vivo,

Formal name: 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-glyceryl ester

Synonyms:  2-AG

Molecular weight: 378.6

CAS: 53847-30-6

Purity: ≥95% (as a 9:1 mixture of the 2-AG and 1-AG)

Formulation: A solution in acetonitrile

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