A fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics

2-Aminopurine (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
1428126-74-2
Storage:
-20
UN-No:
Non-Hazardous - /

2-Aminopurine is a fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics.{30070} It base pairs with cytosine in a wobble configuration or with thymine in a Watson–Crick geometry.{30070} In addition to its usefulness in studies of base stacking interactions, 2-aminopurine has been used as a probe for DNA base flipping by methyl transferases.{30069} 2-Aminopurine exhibits an excitation/emission of 320/381 nm, respectively, when adjusted to reduce interference with DNA base absorption as well as tryptophan fluorescence.{30069} 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase, protein kinase R, whose activity mediates antiviral defense and participates in toll-like receptor signaling.{30068}  

 

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Description

A fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics, such as studies of base stacking interactions and DNA base flipping; ex/em = 320/381 nm, respectively, when adjusted to reduce interference with DNA base absorption as well as tryptophan fluorescence; inhibits PKR

Formal name: 9H-purin-2-amine, dihydrochloride

Synonyms:  2-AP

Molecular weight: 208.1

CAS: 1428126-74-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Viral Diseases

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