A food-derived carcinogen; metabolized by CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts; induces formation of single-base substitutions and exon deletions and increases cell death in vitro; increases incidence of squamous cell hyperplasias in the stomach of p53 knockout mice; increases hepatocellular lesions in female mice regardless of p53 status

2-Amino-3-methylimidazo[4,5-f]quinoline – 50 mg

Brand:
Cayman
CAS:
76180-96-6
Storage:
-20
UN-No:
Non-Hazardous - /

2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a food-derived carcinogen that is found in high temperature-cooked meats and tobacco smoke.{39298} In humans, IQ is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts. It induces formation of single-base substitutions and exon deletions and increases cell death in vitro in a concentration-dependent manner. In vivo, IQ increases the incidence of squamous cell hyperplasias in the stomach of p53 knockout mice and increases hepatocellular lesions in female mice regardless of p53 status.{39299}  

 

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Description

A food-derived carcinogen; metabolized by CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts; induces formation of single-base substitutions and exon deletions and increases cell death in vitro; increases incidence of squamous cell hyperplasias in the stomach of p53 knockout mice; increases hepatocellular lesions in female mice regardless of p53 status,

Formal name: 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine

Synonyms:  IQ

Molecular weight: 198.2

CAS: 76180-96-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|DNA Damage and Repair

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