A selective

2-Acetylphenothiazine – 50 g

Brand:
Cayman
CAS:
6631-94-3
Storage:
4
UN-No:
Non-Hazardous - /

2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 µM.{31204} It does not affect xanthine oxidase-dependent or mitochondrial ROS generation.{31204} 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells.{31204} It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation.{31206} 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1.{31207} 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 µM.{31205}  

 

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Description

A selective, cell-active inhibitor of NOX1 that blocks the generation of ROS in HT-29 cells (IC50 = 0.129 µM); abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM)

Formal name: 1-(10H-phenothiazin-2-yl)-ethanone

Synonyms:  2-APT|ML-171|NSC 169669|NSC 57951

Molecular weight: 241.3

CAS: 6631-94-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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