An inhibitor of S1P lyase in vivo; not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo

2-Acetyl-5-tetrahydroxybutyl Imidazole – 10 mg

Brand:
Cayman
CAS:
94944-70-4
Storage:
-20
UN-No:
Non-Hazardous - /

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate (S1P) lyase in vivo.{13428} THI is not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo, which is subsequently activated by phosphorylation.{45874} In mice, THI (50 µg/ml in drinking water) increases S1P levels by 100-fold in lymphoid tissue and reduces lymphocyte egress from thymus and peripheral lymphoid organs.{13428,17443} The resulting lymphopenia is reversible following cessation of THI treatment.{17442}  

 

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Description

An inhibitor of S1P lyase in vivo; not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo, which is subsequently activated by phosphorylation; reversibly increases S1P levels by 100-fold in lymphoid tissue and reduces lymphocyte egress from thymus and peripheral lymphoid organs in mice at 50 µg/ml in drinking water

Formal name: 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone

Synonyms:  2-Acetyl-4-tetrahydroxybutyl Imidazole|2-ATHBI|THI

Molecular weight: 230.2

CAS: 94944-70-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Lipid Biochemistry|Sphingolipids

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