An inhibitor of GPX4 and inducer of ferroptosis (EC50 = 0.01 µM in HRASV12-expressing BJeHLT cells); reduces tumor volume in various mouse xenograft models

(1S,3R)-RSL3 – 5 mg

Brand:
Cayman
CAS:
1219810-16-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

(1S,3R)-RSL3 is an inhibitor of glutathione peroxidase 4 (GPX4) that induces a lethal accumulation of lipid hydroperoxides and ferroptotic cell death (EC50 = 0.01 µM in HRASV12-expressing BJeHLT cells).{33037,30722,29243} It is selective for HRASV12-expressing over wild-type BJeHLT cells (EC50 = 2 µM).{29243} (1S,3R)-RSL3 reduces tumor volume in various mouse xenograft models, with diffuse large B cell lymphomas and renal cell carcinomas being most sensitive.  

 

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Description

An inhibitor of GPX4 and inducer of ferroptosis (EC50 = 0.01 µM in HRASV12-expressing BJeHLT cells); reduces tumor volume in various mouse xenograft models

Formal name: (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 440.9

CAS: 1219810-16-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase

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