An inhibitor of dopamine biosynthesis (IC50 = 20.7 µM in PC12 cells); inhibits tyrosine hydroxylase activity; inhibits dopamine release in the presence of a high extracellular K+ level (IC50 = 66.5 µM); inhibits L-type and caffeine-activated store-operated Ca2+ channels; prevents Ca2+ leakage from intracellular stores

(1R,9S)-(–)-β-Hydrastine – 5 mg

Brand:
Cayman
CAS:
118-08-1
Storage:
-20
UN-No:
Non-Hazardous - /

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 µM in PC12 cells) by inhibiting tyrosine hydroxylase activity.{38222,38223} It inhibits dopamine release with an IC50 value of 66.5 µM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.{38224,38225}  

 

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Description

An inhibitor of dopamine biosynthesis (IC50 = 20.7 µM in PC12 cells); inhibits tyrosine hydroxylase activity; inhibits dopamine release in the presence of a high extracellular K+ level (IC50 = 66.5 µM); inhibits L-type and caffeine-activated store-operated Ca2+ channels; prevents Ca2+ leakage from intracellular stores,

Formal name: (3S)-6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone

Synonyms: 

Molecular weight: 383.4

CAS: 118-08-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience

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