A major CYP450 metabolite of arachidonic acid that is released from the kidney in response to angiotensin II; a potent vasodilator of renal preglomerular vessels; blocks 20-HETE-induced vasoconstriction of renal arterioles at 1 µM

19(R)-HETE – 25 µg

Brand:
Cayman
CAS:
115461-39-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.{15766} Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.{3825} However, 19(R)-HETE at 1 µM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive.{15771,15772}  

 

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SKU: 10007767 - 25 µg Category:

Description

A major CYP450 metabolite of arachidonic acid that is released from the kidney in response to angiotensin II; a potent vasodilator of renal preglomerular vessels; blocks 20-HETE-induced vasoconstriction of renal arterioles at 1 µM

Formal name: 19R-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid

Synonyms: 

Molecular weight: 320.5

CAS: 115461-39-7

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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