A mineralocorticoid secreted by the zona fasciculata of the adrenal gland; biosynthesis is regulated by ACTH as well as angiotensin II

18-hydroxy-11-deoxy Corticosterone – 500 µg

Brand:
Cayman
CAS:
379-68-0
Storage:
-20
UN-No:
Non-Hazardous - /

18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland.{45039,45040} Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; Item No. 24257) as well as angiotensin II (Item No. 17150), which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells.{45039,45041} 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; Item No. 22916) in human SK-MEL188 melanoma cells.{45042} 18-OH-DOC is an intermediate in the metabolism of progesterone (Item No. 15876) and can be converted to aldosterone (Item No. 15273) by the capsular portion of rat adrenal glands.{45041,45042} Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats.{45040} Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.{45043}  

 

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SKU: 10007851 - 500 µg Category:

Description

A mineralocorticoid secreted by the zona fasciculata of the adrenal gland; biosynthesis is regulated by ACTH as well as angiotensin II, which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells; an intermediate in the metabolism of progesterone; can be formed via conversion of DOC in human SK-MEL188 melanoma cells; can be converted to aldosterone by the capsular portion of rat adrenal glands; increases systolic blood pressure in uninephrectomized saline-drinking rats at 200 μg/rat per day; plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes

Formal name: 18,21-dihydroxy-pregn-4-ene-3,20-dione

Synonyms:  18-Hydroxydeoxycorticosterone|18-OH-DOC

Molecular weight: 346.5

CAS: 379-68-0

Purity:

Formulation: A solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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