A bacterial metabolite with antiangiogenic activity; binds to the SF3b subunit of SAP130

18-Deoxyherboxidiene – 1 mg

Brand:
Cayman
CAS:
1200128-66-0
Storage:
-20
UN-No:
Non-Hazardous - /

18-Deoxyherboxidiene is a bacterial metabolite that has been found in Streptomyces QN18690 and has antiangiogenic activity.{52775} It binds to the SF3b subunit of spliceosome-associated protein 130 (SAP130), SAP145, or SAP155 in HeLa cell extracts when used at 100, 1,000, and 10,000 ng and induces the accumulation of unspliced mRNA in HEK293T cells in a reporter assay. 18-Deoxyherboxidiene inhibits VEGF-induced migration of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner and VEGF-induced HUVEC tube formation when used at a concentration of 0.3 µg/ml.  

 

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SKU: 29063 - 1 mg Category:

Description

A bacterial metabolite with antiangiogenic activity; binds to the SF3b subunit of SAP130, SAP145, or SAP155 in HeLa cell extracts at 100, 1,000, and 10,000 ng; induces the accumulation of unspliced mRNA in HEK293T cells in a reporter assay; inhibits VEGF-induced HUVEC migration in a concentration-dependent manner and VEGF-induced HUVEC tube formation at 0.3 µg/ml

Formal name: (2R,5S,6S)-tetrahydro-6-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-methoxy-1-methylbutyl]-2-methyl-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-5-methyl-2H-pyran-2-acetic acid

Synonyms:  RQN-18690A

Molecular weight: 422.6

CAS: 1200128-66-0

Purity: ≥70%

Formulation: A solid

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