A hydroxy fatty acid formed from DHA by 15-LO and is a precursor to 17(S)-resolvins; inhibits platelet 12-LO (IC50 = 0.4 μM); inhibits TNF-α-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM); inhibits NLRP3 inflammasome formation induced by homocysteine in podocytes at 100 nM

17(S)-HDHA – 250 µg

Brand:
Cayman
CAS:
92693-03-3
Storage:
-20
UN-No:
Excepted Quantity - 1170 / 3

17(S)-HDHA is a hydroxy fatty acid formed from docosahexaenoic acid (DHA; Item No. 90310) by 15-lipoxygenase (15-LO) and is a precursor to 17(S)-resolvins.{13989,46682} 17(S)-HDHA inhibits platelet 12-LO (IC50 = 0.4 μM).{46682} It inhibits TNF-α-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM).{13989} 17(S)-HDHA (100 nM) inhibits NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome formation induced by homocysteine in podocytes.{46683}  

 

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Description

A hydroxy fatty acid formed from DHA by 15-LO and is a precursor to 17(S)-resolvins; inhibits platelet 12-LO (IC50 = 0.4 μM); inhibits TNF-α-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM); inhibits NLRP3 inflammasome formation induced by homocysteine in podocytes at 100 nM

Formal name: 17S-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid

Synonyms:  17(S)-HDoHE|17(S)-hydroxy Docosahexaenoic Acid

Molecular weight: 344.5

CAS: 92693-03-3

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Neuroscience

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