An aspirin-triggered epimer of resolvin D3; has been found in mouse inflammatory exudates; reduces transmigration of neutrophils into the peritoneal cavity

17(R)-Resolvin D3 – 10 µg

Brand:
Cayman
CAS:
1427475-53-3
Storage:
-80
UN-No:
De Minimis - 1170 / 3

17(R)-Resolvin D3 (17(R)-RvD3) is an aspirin-triggered epimer of resolvin D3 (Item No. 13834).{25262} It is produced from docosahexaenoic acid (DHA; Item No. 90310) by COX-2 in the presence of aspirin via a 17(R)-hydroperoxy DHA (17(R)-HDHA; Item No. 10005099) intermediate and has been found in mouse inflammatory exudates.{25262,45355} 17(R)-RvD3 reduces transmigration of isolated human polymorphonuclear cells (PMNs) and induces efferocytosis of apoptotic PMNs by macrophages.{45355} 17(R)-RvD3 (10 ng/animal) reduces transmigration of neutrophils into the peritoneal cavity, as well as decreases the levels of IL-6 and increases the levels of IL-10 in inflammatory exudate in a mouse model of zymosan-induced peritonitis. It activates GPR32 in a β-arrestin reporter assay and increases phagocytosis to a greater degree in CHO cells overexpressing GPR32 compared to mock-transfected cells. 17(R)-RvD3 increases phagocytosis of etoposide-generated tumor cell debris by monocyte-derived macrophages in H460 human lung carcinoma cells in a concentration-dependent manner.{45356} It also inhibits tumor growth in a mouse model of Lewis lung carcinoma when administered at a dose of 0.6 µg/kg per day.  

 

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Description

An aspirin-triggered epimer of resolvin D3; has been found in mouse inflammatory exudates; reduces transmigration of neutrophils into the peritoneal cavity, as well as decreases the levels of IL-6 and increases the levels of IL-10 in inflammatory exudate in a mouse model of zymosan-induced peritonitis at 10 ng/animal; activates GPR32 in a β-arrestin reporter assay and increases phagocytosis to a greater degree in CHO cells overexpressing GPR32 compared to mock-transfected cells; increases phagocytosis of etoposide-generated tumor cell debris by monocyte-derived macrophages in H460 human lung carcinoma cells in a concentration-dependent manner; inhibits tumor growth in a mouse model of Lewis lung carcinoma at 0.6 µg/kg per day

Formal name: (4S,5Z,7E,9E,11R,13Z,15E,17R,19Z)-4,11,17-trihydroxy-5,7,9,13,15,19-docosahexaenoic acid

Synonyms:  17(R)-RvD3|17-epi-Resolvin D3|Aspirin-triggered Resolvin D3|AT-RvD3

Molecular weight: 376.5

CAS: 1427475-53-3

Purity: ≥90%

Formulation: A solution in ethanol

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