An aspirin-triggered epimer of RvD1; reduces human leukocyte transendothelial migration (EC50 = ~30 nM)

17(R)-Resolvin D1 – 25 µg

Brand:
Cayman
CAS:
528583-91-7
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D1 (RvD1; Item No. 10012554) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.{13989} 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).{15718} 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.{15718} In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. Analytical and biological comparisons of synthetic 17(R)-RvD1 with endogenously derived 17(R)-RvD1 have confirmed its identity as matching the natural product.{14569}  

 

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Description

An aspirin-triggered epimer of RvD1; reduces human leukocyte transendothelial migration (EC50 = ~30 nM), and limits leukocyte infiltration in a mouse model of peritonitis

Formal name: 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E19Z-docosahexaenoic acid

Synonyms:  17(R)-RvD1|17-epi-Resolvin D1|Aspirin-triggered Resolvin D1|AT-RvD1

Molecular weight: 376.5

CAS: 528583-91-7

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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