An F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide; expected to show the typical intraocular effects of latanoprost

17-phenyl trinor Prostaglandin F2α amide – 5 mg

Brand:
Cayman
CAS:
155205-89-3
Storage:
-20
UN-No:
De Minimis - 1170 / 3

17-phenyl trinor Prostaglandin F2α amide (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity.{8837} PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.{8941} Although it has been claimed that PG amides are not converted to the free acids in vivo,{8941} studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters.{9311} 17-phenyl trinor PGF2α amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.  

 

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Description

An F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide; expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides

Formal name: 9α,11α,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-amide

Synonyms:  17-phenyl trinor PGF2α amide|Bimatoprost amide

Molecular weight: 387.5

CAS: 155205-89-3

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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