An F-series PG analog which has been approved for use as an ocular hypotensive drug; the ree acid

17-phenyl trinor Prostaglandin F2α ethyl amide – 5 mg

Brand:
Cayman
CAS:
155206-00-1
Storage:
-20
UN-No:
Non-Hazardous - /

17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is an F-series PG analog which has been approved for use as an ocular hypotensive drug.{8941} Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 µg/g corneal tissue/24 hours.{9311} The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.{2058,1374} In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.  

 

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Description

An F-series PG analog which has been approved for use as an ocular hypotensive drug; the ree acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist

Formal name: N-ethyl-9α,11α,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-amide

Synonyms:  15(S)-Bimatoprost|17-phenyl trinor PGF2α ethyl amide|Bimatoprost

Molecular weight: 415.6

CAS: 155206-00-1

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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