A metabolite of lipoxygenase-mediated oxidation of DHA; activates Nrf2-dependent antioxidant gene expression

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid – 25 µg

Brand:
Cayman
CAS:
1233715-28-0
Storage:
-80
UN-No:
De Minimis - 1170 / 3

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity.{16994,16993,18161} It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 µM).{18161}  

 

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SKU: 9000346 - 25 µg Category:

Description

A metabolite of lipoxygenase-mediated oxidation of DHA; activates Nrf2-dependent antioxidant gene expression, acts as a PPARγ agonist (EC50 = ~200 nM), and inhibits pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 µM)

Formal name: 4Z,7Z,10Z,13Z,15E,19Z-17-oxo-docosapentaenoic acid

Synonyms:  17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA|17-oxo-DHA|EFOX

Molecular weight: 342.5

CAS: 1233715-28-0

Purity: ≥90%

Formulation: A solution in ethanol

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