A water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals; has diverse anti-tumor actions; suppresses inflammation by interfering with signaling through the NF-κB pathway; ameliorates high fat diet-induced renal failure

17-DMAG – 10 mg

Brand:
Cayman
CAS:
467214-20-6
Storage:
-20
UN-No:
Non-Hazardous - /

Geldanamycin (Item No. 13355) is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals.{20709} Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer.{20708,18248,20710,20713,20711} This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway.{20712,20714} 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.{20715}  

 

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SKU: 11036 - 10 mg Category:

Description

A water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals; has diverse anti-tumor actions; suppresses inflammation by interfering with signaling through the NF-κB pathway; ameliorates high fat diet-induced renal failure

Formal name: 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-geldanamycin

Synonyms:  Alvespimycin|KOS-1022|NSC 707545

Molecular weight: 616.8

CAS: 467214-20-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cellular Chaperones||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Neuroscience

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