Description
An inhibitor of Hsp90 (IC50s = 5 and 943 nM for BT474 tumor cell and fibroblast Hsp90, respectively); inhibits the growth of prostate cancer cell lines (IC50s = 25-45 nM); promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50s = 4-72 nM); reduces tumor size in a G-415 gallbladder cancer mouse xenograft model at 25 mg/kg ,
Formal name: 17-demethoxy-17-(2-propenylamino)-geldanamycin
Synonyms: BMS 722782|CP 127374|KOS 953|NSC 330507|Tanespimycin
Molecular weight: 585.7
CAS: 75747-14-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones
