A weak estrogen and inhibitor of 5α-reductase; neuroprotective

17α-Estradiol – 1 g

Brand:
Cayman
CAS:
57-91-0
Storage:
-20
UN-No:
Non-Hazardous - /

17α-Estradiol is the natural optical isomer of 17β-estradiol (Item No. 10006315), the major estrogen secreted by the premenopausal ovary. 17α-Estradiol is a less active isomer than its counterpart, displaying 100-fold lower estrogenic activity relative to 17β-estradiol.{24968} It can inhibit 5α-reductase, which plays a role in regulating hair growth. 17α -estradiol is reported to activate the MAPK/ERK and PI3K-Akt signaling pathways via activation of the estrogen receptor-X and has been shown to be neuroprotective after an ischemic stroke and oxidative stress and in transgenic mice with Alzheimer’s disease.{24968,13837}  

 

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Description

A weak estrogen and inhibitor of 5α-reductase; neuroprotective

Formal name: (17α)-estra-1,3,5(10)-triene-3,17-diol

Synonyms:  17-epi Estradiol|17α-Oestradiol|Alfatradiol|NSC 20293|α-Estradiol

Molecular weight: 272.4

CAS: 57-91-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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