A hydroxylated metabolite of estrone as well as an interconversion product with estriol; formed by CYP1A1

16α-hydroxy Estrone – 1 mg

Brand:
Cayman
CAS:
566-76-7
Storage:
-20
UN-No:
Non-Hazardous - /

The naturally-occurring estrogens are estrone (E1, Item No. 10006485), estradiol (E2, Item No. 10006315), and estriol (E3, Item No. 10006484).{9611} 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2.{24474,24473} E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific.{24483} 16α-OHE1 is sulphatized or glucuronidated before excretion.{24483} It is increased in rheumatoid arthritis and decreased by physical activity.{24474,24473} Unlike the parent estrogens and other hydroxylated metabolites of E1, 16α-OHE1 binds covalently and persistently activates estrogen receptors.{24475} In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion.{24474,24483} The levels of 16α-OHE1 are increased in some forms of hormone therapy.{24472} Because hormone therapy increases breast cancer risk, 16α-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive.{24476,24483,24472}  

 

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Description

A hydroxylated metabolite of estrone as well as an interconversion product with estriol; formed by CYP1A1, CYP3A5, CYP3A4, and CYP3A7; binds covalently and persistently activates estrogen receptors; increases cell proliferation and does not suppress TNF-α secretion

Formal name: 3,16α-dihydroxy-estra-1,3,5(10)-trien-17-one

Synonyms:  16α-OHE1

Molecular weight: 286.4

CAS: 566-76-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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