16F16 – 5 mg

Brand:
Cayman
CAS:
922507-80-0
Storage:
-20
UN-No:
Non-Hazardous - /

16F16 is a protein disulfide isomerase (PDI) inhibitor.{54267} It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 µg/ml.{54267} 16F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 µM) reduces HTTN90Q73 mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices.  

 

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Description

A PDI inhibitor; inhibits PDI reductase activity in an enzyme assay from 1-100 µg/ml; reduces HTTQ103-induced PC12 cell apoptosis; suppresses PDI-dependent MOMP in isolated PC12 mitochondria; reduces HTTN90Q73 mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices at 2, 3, 4, and 10 µM; reduces APP-induced pyramidal neuron death in rat corticostriatal slices


Formal name: 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 320.8

CAS: 922507-80-0

Purity: ≥98%

Formulation: A solid


Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease