Description
A monohydroperoxy PUFA produced from arachidonic acid by 12-LO
Formal name: 15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
Synonyms:
Molecular weight: 336.5
CAS: 70981-96-3
Purity: ≥98%
Formulation: A solution in ethanol
15(S)-HpETE – 25 µg
Brand:
Cayman
CAS:
70981-96-3
Storage:
-80
UN-No:
De Minimis - 1170 / 3
15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4{391} or reduced to 15(S)-HETE by peroxidases.{3959,391} 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1.{4194} 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO.{3959,454,588}
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