Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs

15(R)-Iloprost – 5 mg

Brand:
Cayman
CAS:
85026-51-3
Storage:
-20
UN-No:
Non-Hazardous - 1231 / 3

Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.{3347} Iloprost binds with equal affinity to the recombinant human IP and EP receptors with a Ki of 11 nM.{8322} 15(R)-Iloprost is the “unnatural” or inverted C-15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. There are no literature reports of the biological activity of 15(R)-iloprost.  

 

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Description

Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.{3347} Iloprost binds with equal affinity to the human recombinant IP and EP receptors with a Ki of 11 nM.{8322} 15(R)-Iloprost is the “unnatural” or inverted C-15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. There are no literature reports of the biological activity of 15(R)-iloprost.

Formal name: 6,9α-methylene-11α,15R-dihydroxy-16-methyl-prosta-5E,13E-dien-18-yn-1-oic acid

Synonyms: 

Molecular weight: 360.5

CAS: 85026-51-3

Purity: ≥97%

Formulation: A solution in methyl acetate

Product Type|Biochemicals||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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