15(R)-15-methyl PGF2α is a metabolically stable analog of PGF2α. 15(R)-15-methyl PGF2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2α converts it into the active 15(S)-isomer.{4631,1989} The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.{4632}
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A prodrug analog of 15(S)-15-methyl PGF2α designed for activation by gastric acid after oral administration
Formal name: 9α,11α,15R-trihydroxy-15-methyl-prosta-5Z,13E-dien-1-oic acid
Synonyms: 15(R)-15-methyl PGF2α
Molecular weight: 368.5
CAS: 35864-81-4
Purity: ≥95%
Formulation: A solution in methyl acetate
Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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