A metabolite of PGD2 formed by the elimination of two molecules of water; binds to PPARγ with an EC50 value of 2 µM

15-deoxy-Δ12,14-Prostaglandin J2 – 5 mg

Brand:
Cayman
CAS:
87893-55-8
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3

15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1428}  

 

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Description

A metabolite of PGD2 formed by the elimination of two molecules of water; binds to PPARγ with an EC50 value of 2 µM

Formal name: 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid

Synonyms:  15-deoxy-Δ12,14-PGJ2

Molecular weight: 316.4

CAS: 87893-55-8

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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