A metabolite of PGD2 and an agonist of DP2; binds DP2 (Ki = 50 nM) and induces activation of eosinophils (EC50 = 8 nM); induces PPARγ-mediated transcription in a reporter assay at 5 µM; cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml); inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2

15-deoxy-Δ12,14-Prostaglandin D2 – 5 mg

Brand:
Cayman
CAS:
85235-11-6
Storage:
-20
UN-No:
De Minimis - 1231 / 3

15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{11399,11055} It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.{11797} 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml).{1424} It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.{1139}  

 

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SKU: 12700 - 5 mg Category:

Description

A metabolite of PGD2 and an agonist of DP2; binds DP2 (Ki = 50 nM) and induces activation of eosinophils (EC50 = 8 nM); induces PPARγ-mediated transcription in a reporter assay at 5 µM; cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml); inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2

Formal name: 9α-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic acid

Synonyms:  15-deoxy-Δ12,14-PGD2

Molecular weight: 334.5

CAS: 85235-11-6

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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