A metabolite of 14

14,15-Leukotriene E4 – 25 µg

Brand:
Cayman
CAS:
1000852-57-2
Storage:
-80
UN-No:
De Minimis - 1230 / 3|6.1

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.{11267} 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} These metabolites are classified as eoxins because they are formed mostly by eosinophils.{15256} Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.{15256}  

 

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SKU: 10011362 - 25 µg Category:

Description

A metabolite of 14,15-LTC4 and 14,15-LTD4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency compared LTC4, but approximately 100-fold greater potency than histamine

Formal name: 15S-hydroxy-14R-(S-cysteinyl)-5Z,8Z,10E,12E-eicosatetraenoic acid

Synonyms:  14,15-LTE4|Eoxin E4|EXE4

Molecular weight: 439.6

CAS: 1000852-57-2

Purity: ≥97%

Formulation: A solution in methanol

Product Type|Biochemicals|Lipids|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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