A unique LT with weak contractile activity on both guinea pig ileum and pulmonary parenchyma compared to 5-LO-derived LTs; increases vascular permeability of human endothelial cell monolayers with similar potency to that of 5-LO-derived LTs

14,15-Leukotriene C4 – 25 µg

Brand:
Cayman
CAS:
75290-60-7
Storage:
-80
UN-No:
De Minimis - 1230 / 3|6.1

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.{11267} 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils.{15256} However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs.{11158,11187} However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage – a hallmark of inflammation.{15256}  

 

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SKU: 10011360 - 25 µg Category:

Description

A unique LT with weak contractile activity on both guinea pig ileum and pulmonary parenchyma compared to 5-LO-derived LTs; increases vascular permeability of human endothelial cell monolayers with similar potency to that of 5-LO-derived LTs

Formal name: 15S-hydroxy-14R-(S-glutathionyl)-5Z,8Z,10E,12E-eicosatetraenoic acid

Synonyms:  14,15-LTC4|Eoxin C4|EXC4

Molecular weight: 625.8

CAS: 75290-60-7

Purity: ≥95%

Formulation: A solution in methanol

Product Type|Biochemicals|Lipids|Leukotrienes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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