A LTB4 receptor antagonist that has a higher binding affinity for BLT1 (Ki = 27 nM) compared to BLT2 (Ki = 473 nM); inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM

14,15-dehydro Leukotriene B4 – 25 µg

Brand:
Cayman
CAS:
114616-11-4
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.{521,948} It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.{329,82} At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM.{8743} 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.{384}  

 

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Description

A LTB4 receptor antagonist that has a higher binding affinity for BLT1 (Ki = 27 nM) compared to BLT2 (Ki = 473 nM); inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM

Formal name: 5S,12R-dihydroxy-6Z,8E,10E-eicosatrien-14-ynoic acid

Synonyms:  14,15-dehydro LTB4

Molecular weight: 334.5

CAS: 114616-11-4

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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